Mercury Rising 鳯女

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New malaria vaccine

Posted by Charles II on December 9, 2008

Bejon et al., NEJM:

Worldwide, the mortality and morbidity associated with Plasmodium falciparum malaria are high. Progress has been made in controlling malaria by introducing insecticide-treated nets and highly effective artemisinin-based combination treatments. There is evidence that the incidence of malaria is falling in some areas. These advances have renewed interest in the prospects for the control of malaria and even its elimination in areas in which P. falciparum was previously endemic. A safe and affordable vaccine providing protection against malaria would be an important addition to control strategies and should be assessed in the context of the use of insecticide-treated nets and the availability of artemisinin-based combination treatments….

The candidate pre-erythrocytic malaria vaccine RTS,S targets the circumsporozoite protein and has been evaluated in combination with two different adjuvant systems… Preliminary estimates of rates of efficacy against infection after curative antimalarial treatment were 34% (95% confidence interval [CI], 8 to 53) in adults and 66% (95% CI, 43 to 80) in infants. The rate of efficacy against the more clinically relevant end point of clinical malaria in children 1 to 4 years of age was 30% (95% CI, 11 to 45).

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