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Archive for the ‘science and medicine’ Category

Light on your feet …and, farm gushers

Posted by Charles II on June 16, 2015

Anmar Frangoul, CNBC:

Pavegen is a London-based company that is looking to harvest the energy from our footsteps to do precisely this. They have designed and built flooring that converts the kinetic energy we produce when walking into clean, renewable electricity.

“The Pavegen panels convert the weight of your footsteps into electricity, so every time you walk on our product it harnesses a small amount of energy from every single step,” Laurence Kemball-Cook, CEO and Founder of Pavegen, told in a phone interview.

Anmar Frangoul, CNBC:

The global chemical industry is vast, and has an environmental impact to match. According to a 2013 report by International Energy Agency, the chemical and petrochemical sector accounts for approximately seven percent of the world’s greenhouse gas emissions.

One Illinois-based company is working to change an industry which has traditionally relied on oil-based products.

Elevance Renewable Sciences have developed technology and a process that they say enables them to “successfully bridge the renewables and chemicals industries, transforming natural plant-based oils… into speciality high-performance, cost-effective commercial products.”

Posted in energy, environment, science and medicine | 3 Comments »

First, do no harm

Posted by Charles II on February 25, 2015

Gregg Levine, Al-Jazeera:

Perhaps it will not come as a big surprise to learn that the highly trafficked, for-profit medical information site WebMD keeps track of your search terms and then makes some of the information available to third-party vendors. It’s kind of like what the term “for profit” means. But how about one of the other top hits for health-related searches, the Centers for Disease Control? That’s a non-profit government agency — they don’t provide information to marketing interests, right?


Just the thing we want for people who have medical conditions which may endanger the rest of us– a reason to fear that their privacy will be compromised. What is wrong with the CDC (not to mention Mayo and other for-profit sites of institutions that pretend to be engaged in the practice of medicine)?

Posted in abuse of power, science and medicine | 1 Comment »

Good news on the anti-bug front

Posted by Charles II on October 10, 2013

This news is a little old, but I hadn’t heard it. David Heitz, Healthline:

A blood test developed by researchers at Duke University can predict with tremendous accuracy whether someone with, say, pneumonia has a viral or bacterial infection, even if it’s a previously unknown strain.

The test, described today in the journal Science Translational Medicine, could someday help stop the unnecessary prescribing of antibiotics to patients who have viral infections.

In the most recent experiment, 102 subjects with viral and bacterial infections, as well as healthy control patients, arrived at a hospital emergency room and were given the blood test. With about 90 percent accuracy, the test returned the proper diagnosis in just 12 hours.

In larger studies set to begin as early as this flu season, scientists will look at ways of paring down the number of genes the test analyzes and reducing the test’s turnaround time to as little as one hour.

Posted in Good Things, science and medicine | 2 Comments »

Vote for your favorite science cartoon

Posted by Charles II on May 17, 2013

UCS has sponsored a competition here.

Posted in science and medicine | Comments Off on Vote for your favorite science cartoon

The de-leading of America

Posted by Charles II on January 3, 2013

Via Atrios, an article by Kevin Drum, MoJo.

The key takeaway:

A followup is here.

Posted in crimes, environment, science and medicine | 9 Comments »

The need for regulation

Posted by Charles II on December 23, 2012

Kathleen McLaughlin, The Guardian:

International health experts are warning of a mounting health crisis in parts of Africa because of an influx of counterfeit medicine from Asia that is playing havoc with the treatment of diseases such as malaria. Porous borders in Africa coupled with indifferent oversight in China are combining to turn the continent and its pressing health problems into a free-for-all for maverick manufacturers, some of whom are producing pills with no active ingredients at all.

Patrick Lukulay, vice president of the US Pharmacopeial Convention’s global health impact programmes, said it was no secret that the majority of dangerous medications came from China and India, as those countries had the world’s largest production bases for both active ingredients and finished drugs.

While India has stepped up oversight, “China is only now just catching on”, he added.

And more from McLaughlin:

There are fake malaria drugs, antibiotics and even emergency contraceptives. This in a country battling the world’s third highest birthrate, with five to six children per woman keeping the population mired in poverty. Some pills contain no active ingredients, some are partial strength and some the wrong formulation entirely.

“Let’s not exonerate other countries, by the way,” he added, noting that African factories had also been busted for making fakes.

I wish that I could say that the US is not headed in the same direction, but ever since the 1980s, quality standards have been under attack. Not all that long ago, I had a run-in with a flu vaccine that should have been impossible. And, while problems as egregious as those reported by McLaughlin are still rare in the US, other kinds of corner-cutting are common, as evidenced by the many scandals showing substandard clinical testing.

Posted in crimes, science and medicine | 1 Comment »

Obesity: the brain chemistry behind fat

Posted by Charles II on December 5, 2012

A remarkable series of articles on brain chemistry and obesity has been opened to the public by the New York Academy of Sciences.

Kaiser et al. (U. Alabama) give an overview on a hypothesis that, given a perceived deficiency in food availability, the body either adds fat or slows metabolism in a way that lengthens life, depending on whether calories are actually available.

William Banks, VA looks at the role of leptin, a protein that diminishes the desire to eat. In obese people, leptin is, paradoxically, overabundant. This represents a resistance syndrome analogous to insulin resistance. One of the regulators of leptin transport into the brain is triglyceride. In starvation, triglyceride levels rise. Short term fasting increases facilitates leptin transport into the brain, but long-term fasting does the opposite. So fasting can play a positive role in helping to reduce hunger.

Renato Pasquali of Malpighi Hospital in Bologna looks at stress hormones and sex hormones: “stress activates the hypothalamic–pituitary–adrenal (HPA) axis, the sympathetic nervous system (SNS), and the sympathoadrenal system” resulting in the rise of cortisol and catecholamines and an activation of blood pressure elevators like renin and its target, angiotensin. During chronic stress, cortisol elevates lipoprotein lipase, which stores fat especially in the abdomen (perhaps that explains the apple/pear dichotomy, with people with waist fat suffering greater health effects). The term allostatic load refers to the damage inflicted by adapting to adversity. In women, abdominal fat seems to be related to a rise in androgens (male hormones), while in men, to female hormones.

Lucassen et al (NIH and elsewhere) look at the relationship of sleep to obesity. Sleep has declined by over 1.5hr over the last 50 years. Slow wave sleep, which diminishes with age, is probably especially important, though it’s still not clear what’s correlation and what’s causation.

There’s plenty more here.

Posted in health issues, science and medicine | Comments Off on Obesity: the brain chemistry behind fat

The corruption of medicine

Posted by Charles II on September 21, 2012

Ben Goldacre, The Guardian:

In 2010, researchers from Harvard and Toronto found all the trials looking at five major classes of drug – antidepressants, ulcer drugs and so on – then measured two key features: were they positive, and were they funded by industry? They found more than 500 trials in total: 85% of the industry-funded studies were positive, but only 50% of the government-funded trials were. In 2007, researchers looked at every published trial that set out to explore the benefits of a statin. These cholesterol-lowering drugs reduce your risk of having a heart attack and are prescribed in very large quantities. This study found 192 trials in total, either comparing one statin against another, or comparing a statin against a different kind of treatment. They found that industry-funded trials were 20 times more likely to give results favouring the test drug.

These are frightening results, but they come from individual studies. So let’s consider systematic reviews into this area. In 2003, two were published. They took all the studies ever published that looked at whether industry funding is associated with pro-industry results, and both found that industry-funded trials were, overall, about four times more likely to report positive results. A further review in 2007 looked at the new studies in the intervening four years: it found 20 more pieces of work, and all but two showed that industry-sponsored trials were more likely to report flattering results.

Selective publication probably accounts for most of this. But Goldacre is too kind. When a researcher is faced with the prospect of not getting his work published if s/he finds a drug is ineffective, then there is direct pressure to find that the drug is effective. Sometimes, there’s outright intimidation of researchers.

You can read more about reboxetine here. The drug does not work. It produces side effects. It is on the market. Its manufacturers, Pfizer and Lundbeck never published the data that did not make the drug look good.

There’s more, but the message is clear. The drug approval process has been corrupted. The testing process needs to be taken out of the hands of the drug companies.

Posted in abuse of power, science and medicine, working the refs | Comments Off on The corruption of medicine

No one will care that a federal agency has a massive wiretapping operation

Posted by Charles II on July 17, 2012

So what will the FDA do if you get in the way of GE marketing an unsafe colonscopy device? You can read the full megillah here (or in the NYT), or get the executive review from DemocracyNow:

STEPHEN KOHN: Yeah. What they did was they put spyware into the computers. We’re not sure how far it moved. We know it went into thumb drives. It went into their own property. And this spyware enabled them to do keystroke analysis, so they could get all the private passcodes of the scientists. So they could get into their—so they had the ability to get into their medical records, their financial records, their confidential Google-to-Google communications—all that capability, they had.
Read the rest of this entry »

Posted in FDA, science and medicine, wiretapping | 1 Comment »

Antitruth, Inc. How corporations corrupt science.

Posted by Charles II on May 19, 2012

Update: I want to bring the following sentence in the report linked below to attention:

The Obama administration has taken meaningful steps to address political interference in science.

I am not an Obama booster, but I think it’s important to keep some perspective. This sentence would not have been written about President McCain or, especially, Presi..gak Romney.
Francesca Grifo, Michael Halpern, and Peter Hansel, UCS:

Corrupting the Science

Corporations that stand to lose from the results of independent scientific inquiry have gone to great lengths to manipulate and control science and scientists by:

Terminating and suppressing research. Companies have controlled the dissemination of scientific information by ending or withholding results of research that they sponsor that would threaten their bottom line.

Intimidating or coercing scientists. Corporations bury scientific information by harassing scientists and their institutions into silence. Scientists have been threatened with litigation and the loss of their jobs, have had their research defunded, have been refused promotion or tenure, and have been transferred to non-research positions, leading to self-censorship and changes in research direction.

Manipulating study designs and research protocols. Corporations have employed flawed methodologies in testing and research—such as by changing the questions scientists are asking—that are biased toward predetermined results.

Ghostwriting scientific articles. Corporations corrupt the integrity of scientific journals by planting ghostwritten articles about their products.
Rather than submitting articles directly, companies\ recruit scientists or contract with research organizations to publish articles that obscure the
sponsors’ involvement.

Publication bias. Corporations selectively publish positive results while underreporting negative results. While not directly corrupting science itself, these publishing and reporting biases skew the body of evidence.

To be fair, individual scientists do some skunky things, too. If a guy has a pet theory, he’s not likely to immediately publish results that contradict it. He’s more likely to ask for new experiments.

But of course, this is the difference between street crime and organized crime. Street criminals are a nuisance, but easily controlled at the local level. Organized crime has to be confronted with an organized response.

We need corporate science. Those guys study things that would otherwise never be studied, and they enrich science immeasurably–when the science is honest. The real problem is dishonesty, it permeates American society, it proliferates at the corporate level only because workers have limited career choices, and because there’s not much solidarity between scientists. Scientific careers flourish or wither based not on collaboration, but on destructive competition. So government oversight is not the entire answer. But it’s a very important component.

Posted in abuse of power, capitalism as cancer, corporatists, corruption, science and medicine, when government is a good thing | Comments Off on Antitruth, Inc. How corporations corrupt science.

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